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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Patchouli alcohol, Vincristine
Phytochemical Name Patchouli alcohol (PubChem CID: 10955174 )
Anticancer drug Name Vincristine (PubChem CID: 5978 )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Combination Pair ID: 1033
Ref_1
Pair Name Patchouli alcohol, Vincristine
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Down-regulation Expression ABCB1 hsa5243
Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP9 hsa842
Down-regulation Expression CCNE1 hsa898
Down-regulation Expression CD44 hsa960
Down-regulation Expression CDK2 hsa1017
Up-regulation Expression CDKN1A hsa1026
Up-regulation Phosphorylation CHEK1 hsa1111
Up-regulation Phosphorylation CHEK2 hsa11200
Up-regulation Phosphorylation H2AX hsa3014
Down-regulation Expression PROM1 hsa8842
Up-regulation Expression TP53 hsa7157
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
Result Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage
03. Reference
No. Title Href
1 Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage. Thorac Cancer. 2023 Jul;14(21):2007-2017. doi: 10.1111/1759-7714.14982. Click
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